Half of the human population has a defective TMPRSS2 protein that significantly reduces the chance of developing Or analyse the structural impact of missense variants in your own protein withĭatabase to view human sequences and structures and map genetic variantsĮxperimentally determined structures of human proteins and protein complexes, annotated by phenotypic effects of Missense3D-DB: Database of missense variants If you come across what you consider to be clear omissions from theĭatabase, please let me know: Harry Powell There are so many naming conventions in use. Please note the list of available identifiers is not exhaustive as Identifier types are present in the database:Ī search is also performed on the sequence descriptor line. Type a gene name, GI number, Uniprot code, free text etc. Current Phyre2 server load = 0% (normal running) Will give you the answer you require in a fraction of the time. For most users, most of the time, 'normal mode' Please do not use 'intensive mode' unless your search using 'normal mode' indicates that a single model does not cover most of your sequence. Use 'batch' processing (under Expert Mode). If you have more than 5 or 6 sequences to model, it is easier for you (and better for everyone!) if you Sequence against your own in-house structures and those from the Protein Data Bank, as well as models downloaded from the AlphaFold Protein Structure Database. You can use 'One-to-One Threading' to model your Registering for this is quick and easy on our Login page. Log in (top left-hand corner of this web page) to use our Expert Mode features, including batch job submission and One-to-One threading. Follow Homology/analog Y Recognition Engine V 2.0

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